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The most specific antinuclear pattern for SLE is:

A. Rim

B. Speckled

C. Homogenous

D. Nucleolar

A. Although a homogenous pattern is also highly specific for SLE and is the most common pattern in SLE, rim is the most specific. Both are associated with anti-DNA antibodies and antibodies to histone.

Systemic lupus erythematosus is associated with:

A. HLA-DR4

B. HLA-DR2

C. HLA-DQ4

D. HLA-DQ2

B. SLE is associated with HLA-DR2 and -DR3.

Which statement is TRUE about acute cutaneous lupus erythematosus?

A. ACLE occurs in 80 to 90% of patients with SLE.

B. ACLE tends to spare the nasolabial folds.

C. ACLE often flares with systemic disease.

D. Alopecia is common in patients with ACLE.

E. ACLE is the most photosensitive subtype of cutaneous lupus erythematosus.

F. B, C, and D are true.

G. B, C, D, and E are true.

H. All are true.

F. Localized ACLE (malar rash) occurs in only 20 to 60% of patients with SLE, spares the nasolabial folds (unlike dermatomyositis), often flares with systemic disease, and is often associated with alopecia (telogen effluvium–like). Although it is quite photosensitive, it is less so than SCLE.

Which of the following is NOT an ACR criterion of SLE?

A. Complement deficiency

B. Arthritis

C. IgM antiphospholipid antibody positivity

D. Oral ulcers

E. Positive Smith

F. Hemolytic anemia

G. A and C are not

H. A, C, and E are not

I. All of the above are criteria

A. Complement deficiency is the only item that is not an ACR criterion of SLE.

Which medication would NOT cause the following clinical scenarios?

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