TY  - CHAP
M1  - Book, Section
TI  - Aquaporin
A1  - Baumann, Leslie
PY  - 2015
T2  - Cosmeceuticals and Cosmetic Ingredients
AB  - Aquaporins  (AQPs)  are  integral  membrane  proteins  that  form  a  water  channel  and  facilitate  water  transport  in  various  organs  such  as  the  skin,  renal  tubules,  eyes,  the  digestive  tract,  and  the  brain.  In  2003,  Peter  Agre  received  the  Nobel  Prize  in  chemistry  for  discovering  AQPs.  There  are  13  isoforms  of  AQPs  found  in  mammals  classified  as  types  1  to  13.  Functionally,  they  can  be  classified  into  two  subtypes:  AQPs  1,  2,  4,  5,  and  8,  which  only  transport  water,  and  AQPs  3,  7,  9,  and  10,  which  can  conduct  other  substances  such  as  glycerol  (also  known  as  glycerin)  or  urea  in  addition  to  water.1  AQP-3  is  the  predominant  water  channel  found  in  human  epidermis,  and  is  permeable  to  both  water  and  glycerin.  For  years  scientists  have  known  that  glycerin  plays  a  superior  role  in  hydrating  skin,2  but  the  reasons  for  this  became  more  clear  when  AQP-3  was  discovered.  Studies  have  shown  that  defects  in  AQP-3  in  mice  models  result  in  epidermal  dryness  as  well  as  decreased  stratum  corneum  hydration  and  glycerin  content  of  the  epidermis,  followed  by  reduced  elasticity  and  impaired  skin  barrier  recovery.3,4  Aquaporin  facilitates  the  transport  of  water,  glycerin,  and  solutes  between  keratinocytes.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - dermatology.mhmedical.com/content.aspx?aid=1174541949
ER  -