RT Book, Section A1 Ahmed, Rehana L. A2 Soutor, Carol A2 Hordinsky, Maria K. SR Print(0) ID 1177006540 T1 Pruritus in Patients with No Underlying Skin Disease T2 Clinical Dermatology YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071769150 LK dermatology.mhmedical.com/content.aspx?aid=1177006540 RD 2024/04/23 AB Pruritus (itch) is the unpleasant sensation of the skin that results in a desire to scratch. It is a major symptom of many cutaneous and systemic diseases. Pruritus can range from mild to severe, and may be intermittent or chronic (lasting longer than 6 weeks). Pruritus can have a significant impact on health-related quality of life (HRQOL), and has been associated with depression, decreased sleep quality, and global distress.1 The authors of a recent case-control study of patients with chronic pruritus observed that the impact of chronic pruritus on HRQOL may be similar to that of chronic pain.2 Pruritus has multiple etiologies in patients with and without underlying skin disease. The International Forum for the Study of Itch published a clinical classification of pruritus3 in which they proposed 6 categories for pruritus based on the underlying origin: