RT Book, Section
A1 Ho, Allen W.
A1 Kupper, Thomas S.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161321278
T1 Soluble Mediators of the Cutaneous Immune System
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161321278
RD 2024/04/25
AB AT-A-GLANCECytokines  are  polypeptide  mediators  that  function  in  communication  between  hematopoietic  cells  and  other  cell  types.Cytokines  often  have  multiple  biologic  activities  (pleiotropism)  and  overlapping  biologic  effects  (redundancy).Chemokines  and  their  receptors  are  vital  mediators  of  cellular  trafficking.Chemokines  are  synthesized  constitutively  in  some  cells  and  can  be  induced  in  many  other  cell  types.Cytokine  and  chemokine-based  therapeutics  now  in  use  include  recombinant  cytokines,  inhibitory  monoclonal  antibodies,  fusion  proteins  composed  of  cytokine  receptors  and  immunoglobulin  chains,  topical  immunomodulators  such  as  imiquimod,  prevention  of  T-cell  arrest  on  activated  endothelium  or  blocking  infection  of  T  cells  by  human  immunodeficiency  virus  1  using  CC  chemokine  receptor  5  analogs,  and  cytokine  fusion  toxins.