RT Book, Section
A1 Woodley, David T.
A1 Chen, Mei
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161331701
T1 Epidermolysis Bullosa Acquisita
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161331701
RD 2024/04/20
AB AT-A-GLANCERare,  autoimmune  subepidermal  bullous  disease  due  to  immunoglobulin  G  autoantibodies  to  Type  VII  collagen.Etiology  is  unknown.Skin  fragility,  subepidermal  blisters,  residual  scarring,  and  milia  formation.  Common  sites  are  trauma-prone  areas  such  as  hands,  feet,  elbows,  knees,  sacrum,  nails,  and  mouth.Related  features  may  include  an  underlying  systemic  disease  such  as  inflammatory  bowel  disease.  May  have  erosions  of  the  mucosa  and  esophageal  stenosis.Pathology  shows  subepidermal  bulla,  fibrosis,  milia  formation,  and  positive  direct  immunofluorescence  for  immunoglobulin  G  deposits  at  the  epidermal–dermal  junction.Treatment  options  are  limited  and  often  difficult.