RT Book, Section
A1 Fuleihan, Ramsay L.
A1 Paller, Amy S.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161348757
T1 Genetic Immunodeficiency Diseases
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161348757
RD 2024/04/19
AB Primary  immunodeficiency  diseases  are  inherited  disorders  of  the  immune  system  that  result  in  an  increased  susceptibility  to  infection  and  an  increased  morbidity  and  mortality.1  Many  of  these  genetic  immunodeficiency  diseases  are  associated  with  a  variety  of  cutaneous  abnormalities,  and  recognition  of  these  clinical  features  may  allow  an  early  diagnosis  of  primary  immunodeficiency.  Cutaneous  abnormalities  may  include  cutaneous  infections,  atopic-like  or  seborrheic-like  dermatitis,  macular  erythemas,  alopecia,  poor  wound  healing,  purpura,  petechiae,  telangiectasias,  pigmentary  dilution,  cutaneous  granulomas,  extensive  warts,  angioedema,  and  lupus-like  changes  (Table  132-1).  Other  clinical  features  often  include  failure  to  thrive,  visceral  infection,  autoimmune  disorders,  connective  tissue/rheumatologic  diseases,  allergic  reactions,  and  neoplasias.