RT Book, Section
A1 Alavi, Afsaneh
A1 Kirsner, Robert S.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161351153
T1 Wound Healing
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161351153
RD 2024/04/19
AB AT-A-GLANCEWhile  acute  and  chronic  wounds  are  different,  all  chronic  wounds  start  as  an  acute  wound.In  acute  wounds,  there  is  an  orderly  progression  from  injury  to  coagulation,  inflammation,  cell  and  matrix  proliferation,  cell  migration,  and  tissue  remodeling.In  the  initial  phases,  a  wide  range  of  growth  factors,  including  platelet-derived  growth  factor  and  transforming  growth  factor-β1,  play  an  important  role.  In  the  proliferation/migration  and  modeling  phases,  tissue  matrix  metalloproteinases  (MMPs),  integrins,  basic  fibroblast  growth  factor,  and  epidermal  growth  factor  are  critical.  MMP-1,  MMP-9,  and  MMP-10  are  essential  for  remodeling.For  acute  wounds,  moist  wounds  heal  faster,  and  a  variety  of  wound  dressings  are  available,  including  hydrogels,  polyurethane  films,  hydrocolloids,  foams,  alginates,  superabsorbent  dressings,  and  collagen-based  products.In  chronic  wounds,  the  linear  progression  between  the  sequential  phases  of  acute  wound  healing  is  lost.  Chronic  wounds  are  often  the  result  of  ischemia,  pressure,  and  infection;  healing,  in  part,  is  dependent  on  addressing  these  factors.Healing  after  skin  grafting  is  also  different,  as  it  depends  on  revascularization,  either  neovascularization  or  inosculation.