RT Book, Section
A1 Lautenschlager, Stephan
A1 Brockmeyer, Norbert H.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161341463
T1 Chancroid
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161341463
RD 2024/04/19
AB AT-A-GLANCEChancroid  is  a  sexually  transmitted  acute  ulcerative  disease  usually  localized  at  the  anogenital  area  and  often  associated  with  inguinal  adenitis  or  bubo.Haemophilus  ducreyi—a  Gram-negative,  facultative  anaerobic  coccobacillus—is  the  causative  agent.Chancroid  is  disappearing  even  from  most  countries  where  H.  ducreyi  was  previously  epidemic,  with  the  exception  of  North  India  and  Malawi.  Nevertheless,  recent  sporadic  case  reports  from  Western  Europe  have  been  described,  often  initially  misdiagnosed  as  genital  herpes.Painful,  soft  ulcers  with  ragged  undermined  margins  develop  1  to  2  weeks  after  inoculation  (usually  prepuce  and  frenulum  in  men  and  vulva,  cervix,  and  perianal  areas  in  women).H.  ducreyi  facilitates  the  transmission  of  HIV.In  contrast  to  a  sustained  reduction  in  the  proportion  of  genital  ulcer  disease  caused  by  H.  ducreyi,  the  bacterium  is  increasingly  found  in  the  South  Pacific  region  and  in  Africa  as  a  common  cause  of  nongenital  cutaneous  ulcers  especially  in  children.Laboratory  culture  of  H.  ducreyi  is  problematic,  but  greater  sensitivity  can  be  expected  by  nucleic  acid  amplification  methods,  which  are  not  routinely  available.Azithromycin  and  ceftriaxone  are  recommended  as  single-dose  treatment,  enhancing  compliance.