RT Book, Section
A1 Saleem, Mohammed D.
A1 Maibach, Howard I.
A1 Feldman, Steven R.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161343177
T1 Principles of Topical Therapy
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161343177
RD 2024/04/20
AB AT-A-GLANCEEfficacy  of  a  topically  applied  drug  depends  on  three  things:  whether  the  drug  is  applied,  the  delivery  of  the  active  molecule  by  its  vehicle,  and  the  inherent  potency  of  the  active  molecule.Adherence  to  topical  treatment  is  often  poor  and  decreases  over  time.Factors  that  affect  penetration  of  applied  drug  include  soluble  medication  concentration,  regional  variations  in  skin  barrier  properties,  application  frequency,  and  effects  of  the  vehicle  on  barrier  function.The  primary  barrier  that  limits  the  percutaneous  absorption  of  compounds  is  the  stratum  corneum.The  delivery  of  a  topical  agent  is  highly  dependent  on  the  physicochemical  properties  of  the  vehicle;  this  influences  the  kinetics  of  release  and  absorption  and  the  onset,  duration,  and  extent  of  a  biologic  response.Either  the  vehicle  or  its  active  ingredient(s)  may  cause  local  toxicity,  systemic  toxicity,  or  both.