RT Book, Section
A1 O’Connor, Cathal
A1 O’Regan, Grainne M.
A1 Irvine, Alan D.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1162815557
T1 Porokeratosis
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1162815557
RD 2024/04/19
AB AT-A-GLANCEPorokeratosis  is  a  chronic  progressive  disorders  of  keratinization  characterized  clinically  by  hyperkeratotic  papules  or  plaques  surrounded  by  a  threadlike,  elevated  border  that  expands  centrifugally.Porokeratosis  is  genetically  heterogeneous;  the  majority  are  inherited  as  autosomal  dominant  traits.At  least  six  clinical  variants  of  porokeratosis  have  been  described.The  classic  form,  porokeratosis  of  Mibelli,  presents  in  infancy  or  childhood  as  asymptomatic,  small,  brown  to  skin-colored,  annular  papules  with  a  characteristic  raised  border.The  most  common  type,  disseminated  superficial  actinic  porokeratosis,  presents  with  multiple  papules  distributed  symmetrically  on  sun-exposed  areas.Linear  porokeratosis  presents  at  birth  or  in  childhood  with  lesions  distributed  along  Blaschko  lines.Punctate  porokeratosis  appears  during  or  after  adolescence  as  1-  to  2-mm  papules  on  the  palms  or  soles.In  all  variants,  a  thin  column  of  parakeratotic  cells  (cornoid  lamella)  corresponds  to  the  hyperkeratotic  border  and  extends  throughout  the  stratum  corneum  in  histologic  sections.Malignant  epithelial  neoplasms  are  reported  in  all  subtypes  except  the  punctate  variety.