RT Book, Section
A1 Baumann, Leslie
SR Print(0)
ID 1174541590
T1 Barrier Repair Ingredients
T2 Cosmeceuticals and Cosmetic Ingredients
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071793988
LK dermatology.mhmedical.com/content.aspx?aid=1174541590
RD 2024/04/20
AB The  skin  barrier  is  a  watertight  seal  around  the  keratinocytes  in  the  upper  levels  of  the  epidermis.  It  prevents  evaporation  of  water  from  the  surface  of  the  skin,  which  is  known  as  transepidermal  water  loss  (TEWL).  It  is  important  to  note  that  TEWL  is  not  the  same  as  sweating  or  perspiration.  Increased  TEWL  occurs  when  a  defect  in  the  permeability  barrier  allows  excessive  water  to  be  lost  to  the  atmosphere.  The  skin  barrier  decreases  TEWL  and  helps  keep  unwanted  compounds  out  of  the  skin,  such  as  allergens  and  irritants.  Skin  with  an  injured  barrier  is  more  susceptible  to  contact  and  irritant  dermatitis  as  well  as  infection.  Skin  barrier  perturbation  can  be  caused  by  many  different  factors  such  as  detergents,  acetone,  friction,  ultraviolet  exposure,  prolonged  or  frequent  water  immersion,  cholesterol-lowering  drugs,  low-fat  diets,  and  genetic  predisposition  (e.g.,  to  disorders  of  filaggrin).