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Therapeutic approach

Leprosy, a disease of low infectivity caused by the obligate intracellular pathogen Mycobacterium leprae and/or Mycobacterium lepromatosis, is a chronic granulomatous disease which affects mainly the skin and nerves. In disseminated disease of long duration, other organ systems may also be involved. Wide range of clinical manifestation in the patients are due to the variable immunological response of the host to the infection. Medications used to manage leprosy include antibiotics for killing M. leprae and arresting disease progression, anti-inflammatory or immunosuppressives for management of leprosy reactions and analgesics for neuropathic pain (Table 137.1).

Table 137.1Leprosy and Related Complications: Treatment Table

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