|Systemic Therapy |
|Standard WHO regimen for leprosyb |
|Rifampicin ||Part of regular WHO-MDTa,b ||Antibiotic, RNA polymerase inhibitor || |
>14 y: 600 mg once a month, 10-14 y: 450 mg once a month, <10 y: 10 mg/kg once a month.
PB-6 mo, MB-12 mo
|Orange-red discoloration of body fluids, nausea, vomiting, diarrhea, malaise, flu-like syndrome ||Baseline CBC, LFT, RFT, periodic monitoring in patients with baseline derangement (3 mo) ||IA1 |
|Dapsone ||Part of regular WHO-MDTa,b ||Antibiotic, inhibits folic acid metabolism || |
>14 y: 100 mg once daily, 10-14 y: 50 mg once daily, <10 y: 2 mg/kg/d.
PB-6 mo, MB-12 mo
|Dapsone hypersensitivity syndrome, methemoglobinemia, and agranulocytosis ||Baseline CBC, LFT, RFT, G6PD; periodic CBC, LFT (3-6 mo) ||IA1 |
|Clofazimine ||Part of regular WHO-MDTa,b ||Iminophenazine dye, inhibits mitochondrial respiratory chain ||>14 y: 300 mg once a month, 50 mg once daily, 10-14 y: 150 mg once a month, 50 mg every other day, <10 y: 100 mg once a month, 50 mg twice a week; PB-6 mo, MB-12 mo ||Pigmentation of skin, mucosae, body fluids/secretions and xerosis. Prolongation of QT interval ||Gastrointestinal symptoms, skin and mucosae for discoloration at every visit; ECG at baseline, 2 wk, and then every 3 mo and after the addition of any new medication that is known to prolong QT interval ||IA1 |
|WHO regimen for drug-resistant leprosyc |
|Ofloxacin ||Drug-resistant leprosyc ||Antibiotic, DNA gyrase inhibitor ||400 mg once a day for 18 mo ||Nausea, vomiting, diarrhea, headache, tendon rupture. Contraindicated in children below 18 y of age ||Baseline CBC, LFT, RFT, and coagulation profile, periodic CBC, LFT, RFT (3 mo) ||IV2 |
|Clarithromycin ||Drug-resistant leprosyc ||Antibiotic, attaches to bacterial 50 S ribosomal subunit preventing protein synthesis ||500 mg once a day for 18 mo ||Metallic taste, fixed drug eruption, leukocytoclastic vasculitis and hypersensitivity reactions ||RFT, LFT, audiogram with prolonged use, ECG for QTC prolongation ||IV2 |
|Minocycline ||Drug-resistant leprosyc ||Antibiotic, attaches to bacterial 30 S ribosomal subunit preventing protein synthesis ||100 mg once a day for 18 mo ||Acute vestibular adverse effects, hyperpigmentation, ...|