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Therapeutic Approach

Human papillomavirus (HPV) is a common human infection spread by skin-to-skin contact, especially through sexual activity. HPV infections clinically manifest as warts referred to as verrucae and are further characterized based on location and morphology, namely verruca vulgaris, verruca plantaris, verruca plana, verruca filiformis, and condyloma acuminata. Although mainly benign, HPV-infected lesions can transform into malignant neoplasms after persistent infection or infection with the more oncogenic strains (ie, HPV 16, 18, 31, 33). There is no definitive treatment for HPV warts and therapy is aimed at clearance of lesions through various means. No single treatment is superior, but salicylic acid or cryotherapy are common initial choices; other treatments, such as topical/intralesional immunotherapy/chemotherapy, lasers, surgical excision, tend to be reserved for refractory cases. See Table 142-1.

Table 142-1HPV Treatment Table

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