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Therapeutic Approach

Chancroid is a sexually transmitted infection caused by Haemophilus ducreyi and predominant in sub-Saharan Africa, Southeast Asia, and Latin America. Chancroid presents as painful ulcers of the genitalia with associated inguinal lymphadenitis. Therapeutic approach should be selection of antibiotic regimen based on expert guidelines, patient factors, and local susceptibility patterns. See Table 144-1.

Table 144-1Chancroid Treatment Table

Levels of evidence are based on the Journal of the American Academy of Dermatology guidelines: level IA evidence includes evidence from meta-analysis of randomized controlled trials; level IB evidence includes evidence from ≥1 randomized controlled trial; level IIA evidence includes evidence from ≥1 controlled study without randomization; level IIB evidence includes evidence from ≥1 other type of experimental study; level III evidence includes evidence from nonexperimental descriptive studies, such as comparative studies, correlation studies, and case control studies; and level IV evidence includes evidence from expert committee reports or opinions or clinical experience of respected authorities, or both.


1. +
Lautenschlager  S, Kemp  M, Christensen  JJ, Mayans  MV, Moi  H. 2017 European guideline for the management of chancroid. Int J STD AIDS. 2017;28(4):324–329.  [PubMed: 28081686]
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Centers for Disease C. Chancroid—Sexually Transmitted Infections Treatment Guidelines. Published 2021.
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O’Farrell  N, Lazaro  N. UK National Guideline for the management of Chancroid 2014. Int J STD AIDS. 2014;25(14):975–983.  [PubMed: 25080286]
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Workowski  KA, Bachmann  LH, Chan ...

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