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Therapeutic Approach

Sweet syndrome (acute febrile neutrophilic dermatosis) is usually characterized by the sudden onset of pyrexia, neutrophilia in the blood and upper dermis, and tender erythematous skin lesions. In the author’s experience, topical therapy is usually initiated with a high-potency corticosteroid cream or ointment; first-line systemic therapies include corticosteroids, colchicine, and potassium iodide whereas second-line therapies—usually reserved for recalcitrant cases—include indomethacin, dapsone, clofazimine, and cyclosporin. See Table 21-1.

Table 21-1Sweet Syndrome Treatment Table

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