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Therapeutic Approach

Subcorneal pustular dermatosis (SPD) is a rare neutrophilic dermatosis, clinically and pathologically closely related to Immunoglobulin (Ig) A-pemphigus. SPD is characterized by flaccid coalescing sterile pustules often in annular or serpiginous patterns. Its course is chronic and recurrent, and it is frequently associated with monoclonal IgA gammopathy. Histopathologically pustules are subcorneal and neutrophil-rich. Dapsone is the drug of choice in SPD treatment. See Table 23-1.

Table 23-1Subcorneal Pustular Dermatosis Treatment Table

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