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Therapeutic Approach

Acanthosis nigricans is described as a cutaneous disorder characterized by darkening and thickening of the skin along with velvety appearance. It occurs mainly in the folds of the skin including the axillae, inframammary, groin, and neck. Acanthosis nigricans can be a cutaneous sign of an underlying condition or disease and is associated with obesity and diabetes. Very rarely, it can be a warning sign of an internal malignancy. Treatment is largely focused on addressing the underlying disease process. Dermatologic treatment aims to improve the appearance of the skin focusing on reducing the hyperkeratosis, skin lightening, and decreasing odor and discomfort. See Table 66-1.

Table 66-1Acanthosis Nigricans Treatment Table

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