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  • Disorder with the formation of bullae and erosions following mechanical trauma to the skin and mucosa

  • All types of EB patients exhibit fragile skin and blisters. Scarring, nail dystrophy, milia, and scarring alopecia occur in the forms involving the lamina lucida and below

  • Gene defects cause abnormalities in structural proteins of the epidermis and the epidermal-dermal junction

  • Subtypes are classified based on the ultrastructural level of blisters (Table 14-1), mode of inheritance, and the clinical features

  • There are four major EB types (Table 14-2) and multiple related subtypes (Table 14-3)

Table 14-1Ultrastructural Findings Among Major Types and Selected Subtypes of EB
Table 14-2The Four Major EB Types

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