Skip to Main Content


Therapeutic approach

Melanoma is the most serious form of skin cancer causing most of the skin cancer-related deaths. Subtypes include superficial spreading, nodular, lentigo maligna and acral lentiginous.1 Early detection of malignant melanoma remains the key factor in lowering mortality which highlights the importance of the ABCDE screening acronym.2 The prognosis in melanoma is directly proportionate to the depth of the neoplasm, which in turn increases with time.3 Sentinel lymph biopsy is indicated for patients with a significant risk of melanoma metastasis and is used to assess prognosis. Therapy is dictated by stage at diagnosis and can include surgery, small molecule inhibitors, immunotherapy, chemotherapy, and topical therapy. Combination therapy with newer agents have been shown to delay development of resistance and improve treatment outcomes.4 See Table 109-1.

Table 109-1Melanoma Treatment Table

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.