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Therapeutic Approach

Lymphomatoid papulosis (LyP) is a cutaneous lymphoproliferative disorder. LyP typically presents on the trunk and proximal extremities and is characterized by recurrent, dome-shaped, necrotic papules or nodules occurring in cropped or generalized eruptions.1 It follows a chronic, recurrent course, with lesions that appear and spontaneously regress after several weeks with crusting, ulceration, and possible scarring.1 LyP can be classified into 6 major subtypes depending on histologic presentation.2,3 Though LyP does not confer a change in survival, patients are at risk for secondary malignancies, particularly cutaneous or nodal lymphoid malignancies.2 National Comprehensive Cancer Network (NCCN) guidelines suggest observation is the preferred first-line therapeutic approach for asymptomatic lesions. In symptomatic lesions or for patients with numerous, disseminated, or stigmatizing lesions, the therapies below can be used, though observation is still an acceptable first-line option. No therapies have been proven to alter the course of the disease or prevent secondary malignancies.2,4,5 See Table 114-1.

Table 114-1Lymphomatoid Papulosis Treatment Table

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