TY - CHAP M1 - Book, Section TI - Epithelial Precancerous Lesions A1 - Heppt, Markus V. A1 - Schlager, Gabriel A1 - Berking, Carola A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEPrecursor lesions of cutaneous squamous cell carcinoma (SCC).Long-term and cumulative ultraviolet (UV) radiation exposure is the most important etiologic factor in the development of actinic keratoses.Risk factors include fair skin, age, cumulative UV radiation exposure, immunosuppression, prior history of non-melanoma skin cancer.The overall risk of progression to invasive SCC is estimated as 5% to 10%.Treatment is recommended to reduce the risk of SCC formation and to improve patients’ quality of life.Treatment modalities include cryosurgery, shave excision, curettage, dermabrasion, ablative lasers, topical drugs (diclofenac + hyaluronic acid, 5-fluorouracil ± salicylic acid, imiquimod, ingenol mebutate), chemical peelings, and photodynamic therapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - dermatology.mhmedical.com/content.aspx?aid=1161335172 ER -