TY - CHAP M1 - Book, Section TI - Endemic (Nonvenereal) Treponematoses A1 - Bravo, Francisco G. A1 - Talhari, Carolina A1 - Ezzedine, Khaled A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - The endemic treponematoses are infectious diseases caused by microorganisms that are closely related to Treponema pallidum, the causative agent of syphilis. This group of entities includes (1) pinta, caused by Treponema carateum; (2) yaws, caused by T. pallidum ssp. pertenue; and (3) bejel, caused by T. pallidum ssp. endemicum. Although all these entities are caused by Treponema species, there are important differences between the endemic treponematoses and syphilis, including a nonvenereal form of transmission, an endemic occurrence in very specific geographic areas, a tendency to affect children rather than sexually active adults, and a less likely risk for congenital transmission to occur. In common with syphilis, every endemic treponematosis goes through an early stage (including primary and secondary), a period of latency, and a late stage. Significant morbidity is associated with progression of the disease, mainly affecting the skin, bone, and cartilage, leading to significant disfigurement, pain, disability, and social isolation, causing more suffering to already disadvantaged populations living in poverty. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1161341420 ER -