TY - CHAP M1 - Book, Section TI - Botulinum Toxin A1 - Glogau, Richard G. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - When Drs. Jean and Alastair Carruthers made the critical leap from ophthalmologist Dr. Alan Scott’s seminal use of botulinum as an alternative to strabismus surgery to the cosmetic use of the toxin to treat the glabellar frown lines, no one could have predicted the explosive growth of this agent in the commercial market.1 On April 15, 2002, the US Food and Drug Administration (FDA) approved Allergan, Inc.’s Botox Cosmetic* (botulinum toxin type A) for “temporary improvement in the appearance of moderate-to-severe glabellar lines in adult men and women 65 or younger.” This was the first elective cosmetic indication for which any commercially available botulinum toxin in the US market had been approved. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - dermatology.mhmedical.com/content.aspx?aid=1161348210 ER -