TY - CHAP M1 - Book, Section TI - Subepidermal Blistering Diseases A1 - Crowson, A. Neil A1 - Magro, Cynthia M. A2 - Barnhill, Raymond L. A2 - Crowson, A. Neil A2 - Magro, Cynthia M. A2 - Piepkorn, Michael W. A2 - Kutzner, Heinz A2 - Desman, Garrett T. PY - 2020 T2 - Barnhill's Dermatopathology, 4e AB - The epidermis binds to the dermis through the basement membrane (BM) zone, a complex network of interconnecting proteins located at the dermal-epidermal junction.1,2 Perturbing the functions of these proteins, either by mutations3 or circulating autoantibodies,4 leads to loss of tissue adhesion and causes subepidermal blistering diseases. These diseases can be classified into 3 main groups (Fig. 8-1 and Table 8-1)—namely, autoimmune subepidermal blistering diseases, subepidermal blistering diseases due to mutations of proteins of the BM zone, and miscellaneous subepidermal blistering diseases. To understand the subepidermal blistering diseases, their histopathology, and approach to diagnosis, one first requires a comprehension of the ultrastructure and the protein constituents of the basement membrane zone. SN - PB - McGraw Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1178389175 ER -