TY  - CHAP
M1  - Book, Section
TI  - Hormones and Aging Skin
A1  - Zaulyanov-Scanlan, Larissa
A2  - Baumann, Leslie
A2  - Saghari, Sogol
A2  - Weisberg, Edmund
PY  - 2009
T2  - Cosmetic Dermatology: Principles and Practice, 2e
AB  - It  is  well  known  that  estrogen  and  testosterone  play  vital  roles  in  the  development  of  secondary  sexual  characteristics  and  are  important  for  reproduction.  There  are  also  several  ongoing  investigations  on  the  effects  of  these  sex  hormones  in  cardiovascular  disease,  neurodegenerative  disease,  mood,  and  cancer  formation,  as  well  as  into  their  roles  in  adipogenesis  and  osteogenesis  in  women  and  men.  With  so  many  tissues  expressing  estrogen  and  androgen  receptors,  it  is  not  surprising  to  find  that  several  organ  systems  experience  dramatic  changes  as  sex  hormone  levels  decline  with  advancing  age.  The  first  studies  of  sex  hormone  receptors  in  human  skin  and  skin  appendages  began  in  the  mid-1970s  and  examined  estrogen  receptors  in  breast  cancer  tissue,1  and  testosterone  receptors  in  human  hair  follicles.2  Since  that  time  several  studies  have  examined  the  roles  of  sex  hormones  in  a  variety  of  dermatologic  and  other  disease  states.  While  it  has  long  been  known  that  the  skin  has  sex  hormone  receptors,  the  recent  discovery  of  a  second  estrogen  receptor  (ER-β)  has  led  to  much  interest  in  and  new  insights  into  the  effects  of  sex  hormones  on  various  tissues  including  the  skin.  The  aim  of  this  chapter  is  to  review  the  actions  of  sex  hormones  on  the  skin,  specifically  estrogen  and  testosterone,  and  to  examine  the  roles  of  these  hormones  in  skin  aging.  
SN  - 
PB  - The McGraw-Hill Companies, Inc.
CY  - New York, NY
Y2  - 2024/04/19
UR  - dermatology.mhmedical.com/content.aspx?aid=1172445751
ER  -