TY - CHAP M1 - Book, Section TI - Skin Signs of Systemic Disease A1 - Pearson, David R. A2 - Soutor, Carol A2 - Hordinsky, Maria K. PY - 2022 T2 - Clinical Dermatology: Diagnosis and Management of Common Disorders, 2e AB - The skin is immunologically and metabolically dynamic, highly vascular, and directly interfaces with the environment. It also plays a critical role in maintenance of homeostasis, protection, and sensation. As such, cutaneous pathology is a window to many systemic disease processes. A careful history and thorough physical examination of the skin, hair, nails, and mucosal surfaces, paying particular attention to morphology, distribution, and other subtle clinical clues, may result in critical diagnostic, prognostic, and therapeutic benefit that is acquired at the bedside. For example, recognition of nailfold capillary abnormalities may distinguish the hand rash seen in dermatomyositis from that observed in eczema and lead to a diagnosis of interstitial lung disease, or underlying hepatitis C viral infection may be uncovered through identification of oral erosive lichen planus. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - dermatology.mhmedical.com/content.aspx?aid=1190937691 ER -