TY - CHAP M1 - Book, Section TI - Intrinsic Aging A1 - Baumann, Leslie S. A2 - Baumann, Leslie S. A2 - Rieder, Evan A. A2 - Sun, Mary D. PY - 2022 T2 - Baumann’s Cosmetic Dermatology, 3e AB - SUMMARY POINTSWhat’s Important?There is much overlap between intrinsic and extrinsic aging.Keratinocyte and fibroblast functions change with aging.Senescent cells develop a secretory phenotype that accelerates aging.What’s New?Emerging research is demonstrating the importance of the “tissue skeleton,” consisting of fibroblasts and their attachments to the ECM molecules.Lipofuscin contributes to skin aging by reducing the activity of the proteasome.Autophagy decreases the rate of aging. Mitochondrial autophagy is especially important.What’s Coming?Research evaluating the effects of mechanoforces between fibroblasts and the ECM and ascertaining how these change with age.Understanding the changes in mechanoforces and how they affect genetic expression and fibroblast function.Identifying epigenetic methylation patterns of aged skin.Controlling macroautophagy of mitochondria may be an anti-aging strategy in the future.Timely clearance of senescent cells before they create too much damage may be an approach to prevent skin aging. SN - PB - McGraw Hill LLC CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1190667226 ER -