TY - CHAP M1 - Book, Section TI - Cutaneous Squamous Cell Carcinoma A1 - Ashrafzadeh, Sepideh A1 - Waldman, Abigail A2 - Nouri, Keyvan PY - 2023 T2 - Skin Cancer: A Comprehensive Guide AB - SUMMARYSquamous cell carcinoma (SCC) is the malignant neoplasm of keratinocytes. It is the second most common type of skin cancer worldwide.The main pathogenic contributors to SCC are light skin pigmentation, extensive exposure to ultraviolet (UV) radiation, chronic inflammation or scarring, and chronic immunosuppression.Biopsy facilitates both diagnosis of SCC and identification of histopathologic variants of SCC.Treatment options for SCC are based on tumor and patient characteristics that affect the risk of SCC recurrence and metastasis. Treatments for low-risk SCC include standard excision, electrodesiccation and curettage, and radiation therapy. Treatments for high-risk SCC include Mohs micrographic surgery, excision with complete margin assessment, standard excision, radiation therapy, and chemotherapy.Treatment for SCC with nodal or distant metastases should be formulated in multidisciplinary teams; management plans may include surgery, radiation, programmed death-1 (PD-1) inhibitors, epidermal growth factor receptor (EGFR) inhibitors, and systemic chemotherapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - dermatology.mhmedical.com/content.aspx?aid=1194724030 ER -