TY  - CHAP
M1  - Book, Section
TI  - Basic Science of the Dermis
A1  - Baumann, Leslie S.
A2  - Baumann, Leslie S.
A2  - Rieder, Evan A.
A2  - Sun, Mary D.
PY  - 2022
T2  - Baumann’s Cosmetic Dermatology, 3e
AB  - SUMMARY  POINTSWhat’s  Important?Fibroblasts  produce  collagen,  elastin  precursors,  and  ECM  constituents  such  as  hyaluronic  acid  and  heparan  sulfate.Young  skin  is  characterized  by  elongated  fibroblasts  that  are  more  productive  (synthesize  more  collagen  and  ECM  components)  than  those  in  older  skin.Old  fibroblasts  become  compact  and  have  less  connection  to  the  ECM.What’s  New?The  tissue  skeleton  connects  the  fibroblast  genomic  DNA  to  the  ECM.The  fibroblast  connects  to  the  ECM  and  exerts  “mechanoforces”  that  affect  gene  expression.Geometrical  changes  in  the  nucleus  of  the  fibroblast  influence  gene  transcription.The  matrisome,  or  microenvironment  of  the  ECM,  affects  the  gene  expression  of  fibroblasts.Papillary  fibroblasts  and  reticular  fibroblasts  exhibit  a  29%  difference  in  gene  expression1  and  different  cell  markers.What’s  Coming?Linkers  of  the  nucleoskeleton  and  cytoskeleton  (LINCS)  are  connected  to  genomic  DNA.  Research  is  ongoing  to  understand  how  LINCS  affects  DNA  expression  and  to  which  signals  they  respond.Ongoing  research  is  assessing  the  tissue  skeleton  and  modulations  that  occur  with  aging.More  is  to  be  learned  about  epigenetics  and  the  effects  on  fibroblast  function.More  will  be  learned  about  cannabinoid  receptors  and  fibroblasts.  
SN  - 
PB  - McGraw Hill LLC
CY  - New York, NY
Y2  - 2024/04/19
UR  - dermatology.mhmedical.com/content.aspx?aid=1197532041
ER  -