TY  - CHAP
M1  - Book, Section
TI  - Merkel Cell Carcinoma
A1  - Emanuel, Patrick
A1  - Izzard, Mark
A2  - Emanuel, Patrick
A2  - Izzard, Mark
PY  - 2023
T2  - Margin Control Surgery of the Skin: Concepts, Histopathology, and Applications
AB  - Merkel  cell  carcinoma  (MCC)  is  an  aggressive  neuroendocrine  carcinoma  of  the  skin  with  high  rates  of  metastasis  and  death.  It  was  first  described  by  Cyril  Toker  in  1972  who  called  it  trabecular  carcinoma.  Later,  it  was  named  after  the  Merkel  cells  (specialized  pressure  receptor  cells  in  the  epidermis)  as  these  are  histologically  and  immunophenotypically  like  MCC  tumor  cells.  MCC  is  most  common  in  the  7th  to  9th  decades  of  life  and  frequently  arises  on  chronically  sun-exposed  skin  of  the  head  and  neck  (>40%).  Immunosuppression  is  also  a  risk  factor  with  higher  rates  in  patients  with  hematological  malignancy,  HIV,  and  iatrogenic  immunosuppression.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/18
UR  - dermatology.mhmedical.com/content.aspx?aid=1199483237
ER  -