TY - CHAP M1 - Book, Section TI - Atopic Dermatitis A1 - Simpson, Eric L. A1 - Leung, Donald Y. M. A1 - Eichenfield, Lawrence F. A1 - Boguniewicz, Mark A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEAtopic dermatitis (AD) has a prevalence peak of 15% to 20% in early childhood in industrialized countries.AD has variable rates of remission, with many patients continuing or recurring with symptoms into adulthood.AD is a chronic or chronically relapsing disorder with major features of:PruritusEczematous dermatitis (acute, subacute, or chronic) with typical morphology and age-specific patternsFacial and extensor involvement in infancyFlexural eczema or lichenification in children and adultsCommonly associated with the following:Personal or family history of atopy (allergic rhinitis, asthma, atopic dermatitis)Xerosis or skin barrier dysfunctionImmunoglobulin E reactivityPathogenesis driven by skin barrier defects (most importantly in the FLG gene), environmental effects and alterations in immunologic responses in T cells, antigen processing, inflammatory cytokines, host defense proteins, allergen sensitivity, and infection. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - dermatology.mhmedical.com/content.aspx?aid=1161322297 ER -