TY - CHAP M1 - Book, Section TI - Acquired Perforating Disorders A1 - Desman, Garrett T. A1 - Barnhill, Raymond L. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEAcquired perforating disorders represent a group of separately identified cutaneous disorders that occur most often in the setting of chronic renal disease or diabetes mellitus.The previously recognized Kyrle disease (KD), acquired elastosis perforans serpiginosa (AEPS), acquired perforating collagenosis (APC), and perforating folliculitis (PF) are now classified under the umbrella term of acquired perforating dermatosis.Lesions present as umbilicated papules and/or nodules with a central keratotic plug or crust distributed preferentially on extensor surfaces of the extremities.Histopathologic examination of lesional skin demonstrates invagination of the epidermis with extrusion of dermal material (collagen, elastin, and/or fibrin) through the cup-shaped epidermal depression.Treatment is challenging with no universally effective therapy, and patients often exhibit a chronic course. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1161323376 ER -