TY - CHAP M1 - Book, Section TI - Epidermolysis Bullosa Acquisita A1 - Woodley, David T. A1 - Chen, Mei A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCERare, autoimmune subepidermal bullous disease due to immunoglobulin G autoantibodies to Type VII collagen.Etiology is unknown.Skin fragility, subepidermal blisters, residual scarring, and milia formation. Common sites are trauma-prone areas such as hands, feet, elbows, knees, sacrum, nails, and mouth.Related features may include an underlying systemic disease such as inflammatory bowel disease. May have erosions of the mucosa and esophageal stenosis.Pathology shows subepidermal bulla, fibrosis, milia formation, and positive direct immunofluorescence for immunoglobulin G deposits at the epidermal–dermal junction.Treatment options are limited and often difficult. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1161331701 ER -