TY - CHAP M1 - Book, Section TI - Wound Healing A1 - Alavi, Afsaneh A1 - Kirsner, Robert S. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEWhile acute and chronic wounds are different, all chronic wounds start as an acute wound.In acute wounds, there is an orderly progression from injury to coagulation, inflammation, cell and matrix proliferation, cell migration, and tissue remodeling.In the initial phases, a wide range of growth factors, including platelet-derived growth factor and transforming growth factor-β1, play an important role. In the proliferation/migration and modeling phases, tissue matrix metalloproteinases (MMPs), integrins, basic fibroblast growth factor, and epidermal growth factor are critical. MMP-1, MMP-9, and MMP-10 are essential for remodeling.For acute wounds, moist wounds heal faster, and a variety of wound dressings are available, including hydrogels, polyurethane films, hydrocolloids, foams, alginates, superabsorbent dressings, and collagen-based products.In chronic wounds, the linear progression between the sequential phases of acute wound healing is lost. Chronic wounds are often the result of ischemia, pressure, and infection; healing, in part, is dependent on addressing these factors.Healing after skin grafting is also different, as it depends on revascularization, either neovascularization or inosculation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - dermatology.mhmedical.com/content.aspx?aid=1161351153 ER -