TY - CHAP M1 - Book, Section TI - Syphilis A1 - Tuddenham, Susan A. A1 - Zenilman, Jonathan M. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEA disease caused by the spirochete Treponema pallidum subspecies pallidum that is almost exclusively sexually transmitted.In the United States, syphilis disproportionately affects men who have sex with men and African American heterosexual communities.The most common and recognizable manifestations are usually cutaneous.Syphilis passes through 4 distinct clinical phases:Primary stage, characterized by a chancre.Secondary stage, characterized typically by skin eruption(s) with or without lymphadenopathy and organ disease.A latent period of varied duration, characterized by the absence of signs or symptoms of disease, with only reactive serologic tests as evidence of infection.Tertiary stage, with cutaneous, neurologic, or cardiovascular manifestations.Neurosyphilis and ophthalmic syphilis can occur at any stage.The recommended treatment for most types of syphilis is benzathine penicillin G, with dose and administration schedule determined by disease stage.Any patient diagnosed with syphilis should be tested for other sexually transmitted infections, including HIV. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1161341272 ER -