TY - CHAP M1 - Book, Section TI - The Rickettsioses, Ehrlichioses, and Anaplasmoses A1 - Liaqat, Maryam A1 - Halpern, Analisa V. A1 - Green, Justin J. A1 - Heymann, Warren R. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. Y1 - 2019 N1 - T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCERickettsiae primarily target vascular endothelial cells, causing febrile illness and rash in the mammalian host.Transmission is predominantly via tick bites, with certain pathogens transmitted by human body lice and mites.Fever, headache, myalgia, and malaise are common to rickettsial, ehrlichial, and Anaplasma infections; rash is common in rickettsial disease, occasional in ehrlichial infection, and rare in anaplasmosis.The early signs and symptoms of infection are often nonspecific and can mimic self-limited viral illnesses or other life-threatening illnesses.Early empiric treatment with doxycycline should be considered in highly suspicious cases until rickettsial infection is definitively ruled out, as delayed treatment can lead to severe sequelae and high mortality rates. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - dermatology.mhmedical.com/content.aspx?aid=1161342659 ER -