TY - CHAP M1 - Book, Section TI - Neurofibromatosis A1 - Yoshida, Yuichi A2 - Kelly, A. Paul A2 - Taylor, Susan C. A2 - Lim, Henry W. A2 - Serrano, Ana Maria Anido Y1 - 2016 N1 - T2 - Taylor and Kelly's Dermatology for Skin of Color, 2e AB - KEY POINTSNeurofibromatosis type 1 (NF1) is a neurocutaneous genetic disorder caused by mutation of the NF1 gene on chromosome 17q11.2, whereas neurofibromatosis type 2 (NF2) is a genetically distinct disorder caused by mutation of the gene on chromosome 22q12.2 encoding merlin.The worldwide prevalence of NF1 is approximately 1 in 3000 individuals with no relation to race.NF1 is characterized by café-au-lait spots, freckling, neurofibromas, Lisch nodules, cerebral tumors, and osseous abnormalities.Clinical manifestations of NF1 are variable in each individual, and the overall degree of severity and complications are not predictable.Patients with NF1 have increased risk of malignancies.Age-specific annual monitoring and treatment of complications by appropriate specialists are important for management of NF1. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1161548982 ER -