TY  - CHAP
M1  - Book, Section
TI  - Spongiotic Dermatitis
A1  - Jhorar, Preeti
A1  - Murphy, Michael
A1  - Grant-Kels, Jane M.
A2  - Barnhill, Raymond L.
A2  - Crowson, A. Neil
A2  - Magro, Cynthia M.
A2  - Piepkorn, Michael W.
A2  - Kutzner, Heinz
A2  - Desman, Garrett T.
Y1  - 2020
N1  - 
T2  - Barnhill's Dermatopathology, 4e
AB  - The  term  “spongiotic  dermatitis”  refers  to  a  large  group  of  inflammatory  disorders  that  share  the  histopathologic  finding  of  spongiosis,  characterized  by  impairment  of  cohesion  between  epidermal  keratinocytes  and  intercellular  edema  (Fig.  2-1  and  Table  2-1).  Spongiosis  is  the  hallmark  of  eczematous  dermatitides  but  can  be  seen  in  a  variety  of  other  skin  conditions  (Table  2-2).  Both  T  lymphocytes  and  keratinocytes  are  thought  to  play  major  roles  in  the  pathogenesis  of  spongiotic  dermatitis.1,2  Skin-infiltrating  T  cells  damage  the  epidermis  by  releasing  pro-inflammatory  cytokines  and  induce  keratinocyte  apoptosis  through  “killer  molecules.”1,2  There  is  subsequent  cleavage  of  adhesion  molecules,  including  E-cadherin,  on  keratinocytes.1,2  Accumulation  of  extracellular  fluid  results  in  widening  of  the  spaces  between  keratinocytes,  causing  the  epidermis  to  resemble  a  sponge  histologically.1,2  
SN  - 
PB  - McGraw Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - dermatology.mhmedical.com/content.aspx?aid=1178387325
ER  -