TY - CHAP M1 - Book, Section TI - Barrier Repair Ingredients A1 - Baumann, Leslie Y1 - 2015 N1 - T2 - Cosmeceuticals and Cosmetic Ingredients AB - The skin barrier is a watertight seal around the keratinocytes in the upper levels of the epidermis. It prevents evaporation of water from the surface of the skin, which is known as transepidermal water loss (TEWL). It is important to note that TEWL is not the same as sweating or perspiration. Increased TEWL occurs when a defect in the permeability barrier allows excessive water to be lost to the atmosphere. The skin barrier decreases TEWL and helps keep unwanted compounds out of the skin, such as allergens and irritants. Skin with an injured barrier is more susceptible to contact and irritant dermatitis as well as infection. Skin barrier perturbation can be caused by many different factors such as detergents, acetone, friction, ultraviolet exposure, prolonged or frequent water immersion, cholesterol-lowering drugs, low-fat diets, and genetic predisposition (e.g., to disorders of filaggrin). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1174541590 ER -