TY  - CHAP
M1  - Book, Section
TI  - Antimetabolites and Antimitotic Drugs in the Treatment of Keloid and Hypertrophic Scars
A1  - Waldman, Abigail
A1  - Alam, Murad
A2  - Alam, Murad
A2  - Dover, Jeffrey S.
A2  - Waibel, Jill S.
A2  - Arndt, Kenneth A.
A2  - Kim, John Y. S.
A2  - Thomas, J. Regan
A2  - Gaball, Curtis W.
A2  - Chan, Rodney K.
Y1  - 2021
N1  - 
T2  - Treatment of Scars From Burns and Trauma
AB  - In  addition  to  procedural  interventions,  and  often  in  combination  with  these,  antimetabolite  and  antimitotic  drugs  can  be  used  to  treat  hypertrophic  scars  and  keloids  while  also  mitigating  their  likelihood  of  recurrence.  Such  drugs  can  be  administered  topically,  intralesionally,  or  orally.  Intralesional  5-fluorouracil,  a  pyrimidine  analogue  with  antimetabolite  activity  that  inhibits  fibroblast  proliferation,  is  the  most  common  antimetabolite  agent  for  thickened  scars.  Other  options  include  oral  methotrexate,  an  antimetabolite  (antifolate)  that  prevents  reduction  of  folate  to  its  active  form  by  inhibiting  dihydrofolate  reductase;  intralesional  bleomycin,  a  cytotoxic  antibiotic  derived  from  Streptomyces  verticellus  that  has  been  shown  to  inhibit  collagen  synthesis  and  induce  apoptosis;  oral  colchicine,  an  antimitotic  agent  believed  to  interfere  with  cell  division  through  its  disruptive  action  on  the  mitotic  spindle,  whereby  it  manifests  a  specific  and  dose-dependent  inhibitory  effect  on  collagen  synthesis  and  fibroblast  proliferation;  and  topical  mitomycin  C,  a  cytotoxic  antineoplastic  antibiotic  produced  by  Streptomyces  caespitosus,  with  antiproliferative  effects  on  fibroblasts  through  DNA  synthesis  inhibition.  Notably,  virtually  all  of  these  scar  reduction  treatments,  while  evidence-based,  are  off-label  indications  for  these  drugs.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/25
UR  - dermatology.mhmedical.com/content.aspx?aid=1176880336
ER  -