TY - CHAP M1 - Book, Section TI - Kaposi Sarcoma A1 - Zakka, Kimberley A1 - Rajabi-Estarabadi, Ali A1 - Nouri, Keyvan A2 - Nouri, Keyvan Y1 - 2023 N1 - T2 - Skin Cancer: A Comprehensive Guide AB - SUMMARYThere are four major subtypes of Kaposi sarcoma (KS): classic, endemic, HIV-associated, and iatrogenic. Clinical characteristics overlap, but certain features are more prominent in some variants than in others.KS requires infection with human herpesvirus-8 (HHV-8), though this is not sufficient to cause the neoplasm. Most patients have some level of immune dysregulation.Histologically, KS presents as a patch, plaque, or nodule characterized by spindle cell vascular proliferation with extravasated red blood cells, lymphocytic infiltrates, and hyaline globules.Therapy selection is based on clinical subtype, disease progression, distribution, and severity. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - dermatology.mhmedical.com/content.aspx?aid=1194725563 ER -