TY - CHAP M1 - Book, Section TI - Developmental Biology of the Skin A1 - Garza, Luis A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - Cell lineage: The family tree history of a cell through all of its divisions.Clone: Any distinct cell and all of its progeny.Differentiation: The process where a cell becomes increasingly specialized in their cellular lineage. The least-differentiated cells are the totipotent embryonic stem cells which can develop into any cell in the body. The most differentiated cells are restricted to their type and have the least potential to become another type of cell. The differentiation status of a cell is usually firm, and in most cases thought to be irreversible. This chapter essentially discusses how the least-differentiated cells eventually form skin and become differentiated to the terminal cells of a mature organism.Dedifferentiation: The process where a cell might reverse its otherwise fixed differentiation status.Epithelial–Mesenchymal Interactions: This describes the crosstalk between keratinocytes and fibroblast during morphogenesis.Regenerative Medicine: The field whose goal is to harness the concepts of developmental biology for dedifferentiation of adult tissues and allow reactivation of embryonic programs for the recreation of lost structures.Chimerism or Mosaicism: During development, the emergence of genetic mutations in an otherwise normal animal which create distinct lineages of mutant cells or clones.Blaschko Lines: The migration pattern of skin cells during embryonic development can be visualized in adults if that individual is a chimera and a distinct clone has a clinical abnormality such that it is visible in the background of other skin cells. This is most obvious with the keratinocyte mutations that occur in utero during skin morphogenesis such that they are intermixed with normal cells. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1161320534 ER -