TY  - CHAP
M1  - Book, Section
TI  - Pigmentation and Melanocyte Biology
A1  - Ostrowski, Stephen M.
A1  - Fisher, David E.
A2  - Kang, Sewon
A2  - Amagai, Masayuki
A2  - Bruckner, Anna L.
A2  - Enk, Alexander H.
A2  - Margolis, David J.
A2  - McMichael, Amy J.
A2  - Orringer, Jeffrey S.
PY  - 2019
T2  - Fitzpatrick's Dermatology, 9e
AB  - AT-A-GLANCEDevelopment  of  MelanocytesMelanocytes  are  derived  from  neural  crest  lineageTranscription  factors  (MITF,  SOX10,  PAX3)  and  signaling  pathways  (KIT,  EDNRB)  that  are  important  for  development,  migration,  and  survival  of  melanocytes  also  play  key  roles  in  melanomaFunction  of  melanocytesKey  function  of  melanocytes  is  to  synthesize  melanin  and  transfer  to  surrounding  keratinocytesMelanocytes  can  produce  brown/black  melanin  (eumelanin)  or  orange/yellow  melanin  (pheomelanin)The  melanosome,  a  specialized  lysosome-related  organelle,  is  the  site  of  melanin  synthesis  and  storageRegulation  of  human  pigmentationCommon  human  variants  in  melanocortin  1  receptor  (MC1R)  lead  to  the  “red  hair  phenotype”—red  hair,  fair  skin,  inability  to  tan,  and  increased  melanoma  riskMC1R  signals  to  the  MITF  transcription  factor  to  regulate  pigmentation  and  sun-tanning  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - dermatology.mhmedical.com/content.aspx?aid=1161322062
ER  -