TY  - CHAP
M1  - Book, Section
TI  - Tuberous Sclerosis Complex
A1  - Darling, Thomas N.
A2  - Kang, Sewon
A2  - Amagai, Masayuki
A2  - Bruckner, Anna L.
A2  - Enk, Alexander H.
A2  - Margolis, David J.
A2  - McMichael, Amy J.
A2  - Orringer, Jeffrey S.
PY  - 2019
T2  - Fitzpatrick's Dermatology, 9e
AB  - AT-A-GLANCEAutosomal  dominant  syndrome  with  variable  expressivity.Manifested  by  hamartomatous  tumors  in  multiple  organs,  including  brain  (causing  seizures),  eyes,  heart,  kidneys,  lungs,  and  skin.Skin  lesions  occur  in  nearly  all  individuals  and  are  important  for  diagnosis.Skin  lesions  include  hypomelanotic  macules,  “confetti”  lesions,  facial  angiofibromas,  fibrous  cephalic  plaques,  shagreen  patches,  and  ungual  fibromas.Hypomelanotic  macules  appear  at  birth  or  shortly  thereafter  and  are  most  useful  in  early  diagnosis.Although  the  skin  lesions  are  benign,  they  may  require  treatment  because  of  symptoms  or  disfigurement.Skin  lesions  can  be  treated  with  surgery  or  topical  sirolimus.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - dermatology.mhmedical.com/content.aspx?aid=1161349343
ER  -