TY - CHAP M1 - Book, Section TI - Sweet Syndrome A1 - Cohen, Philip R. A1 - Kurzrock, Razelle A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCESweet syndrome, also referred to as acute febrile neutrophilic dermatosis, is characterized by a constellation of symptoms and findings: the acute onset of fever, neutrophilia, tender erythematous skin lesions that typically show mature neutrophils in the upper dermis, and—after initiation of systemic corticosteroids—a prompt improvement of both symptoms and lesions.Extracutaneous manifestations of Sweet syndrome can include cardiovascular, central nervous system, gastrointestinal, hepatic, musculoskeletal, ocular, oral, otic, pulmonary, renal, and splenic organs.Infection of the upper respiratory tract and/or gastrointestinal tract, inflammatory bowel disease, and pregnancy may be associated with classical Sweet syndrome.In individuals with previously undiagnosed or relapsing hematologic malignancies and solid tumors, malignancy-associated Sweet syndrome may occur as a cutaneous paraneoplastic syndrome.The onset of the dermatosis in patients following the initiation of certain medications—drug-induced Sweet syndrome—is most commonly associated with granulocyte colony-stimulating factor.The pathogenesis of Sweet syndrome remains to be established; cytokines—directly or indirectly—may have an important etiologic role.Corticosteroids, potassium iodide, and colchicine are the first-line oral systemic agents for treating Sweet syndrome.Indomethacin, clofazimine, cyclosporine, and dapsone are the second-line oral systemic agents for treating Sweet syndrome.Localized Sweet syndrome lesions may be effectively treated with the topical application of high-potency corticosteroids or intralesional corticosteroids. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1162813389 ER -