TY - CHAP M1 - Book, Section TI - Pemphigus A1 - Payne, Aimee S. A1 - Stanley, John R. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCETwo major types: pemphigus vulgaris and pemphigus foliaceus.Pemphigus vulgaris: erosions on mucous membranes and skin; flaccid blisters on skin.Pemphigus foliaceus: crusted, scaly skin lesions.Pemphigus vulgaris histology: suprabasal acantholysis.Pemphigus foliaceus histology: subcorneal acantholysis.Autoantigens are desmogleins, transmembrane desmosomal adhesion molecules.Diagnosis depends on histology showing intraepidermal acantholysis, immunofluorescence studies documenting the presence of cell surface autoantibodies, either bound to patient skin or in the serum, and/or enzyme-linked immunosorbent assay showing anti-desmoglein antibodiesTherapy includes topical and systemic corticosteroids, oral immunosuppressive agents, intravenous immunoglobulin, and rituximab (anti-CD20 monoclonal antibody). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - dermatology.mhmedical.com/content.aspx?aid=1162815696 ER -