TY - CHAP M1 - Book, Section TI - Melanoma and Non-Melanoma Skin Cancer A1 - Aasi, Sumaira A1 - Longmire, Michelle A2 - Ali, Asra PY - 2015 T2 - McGraw-Hill Education Specialty Board Review Dermatology: A Pictorial Review, 3e AB - Negative cancer regulatorsCause apoptosis of DNA-damaged cells and block cell divisionEncode cell-cycle regulators, adhesion molecules, DNA repair enzymes, or signal transduction pathway moleculesp53 most common cancer mutation, present in one-half of all human cancers; ninety percent of squamous cell carcinomas (SCCs) and in most basal cell carcinomas (BCCs) and actinic keratosis (Fig. 12-1)PTCH1 member of the patched gene family that acts as a tumor suppressor in BCC.CDKN2 mutation of this tumor suppressor leads to familial syndrome of pancreatic cancer and melanomaARF functions as a melanoma tumor suppressor by inducing p53-independent senescence SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - dermatology.mhmedical.com/content.aspx?aid=1176106812 ER -