TY - CHAP M1 - Book, Section TI - Cutaneous Adverse Drug Reactions A1 - Konstantinov, Nikifor K. A1 - Bigliardi, Paul L. A2 - Soutor, Carol A2 - Hordinsky, Maria K. PY - 2022 T2 - Clinical Dermatology: Diagnosis and Management of Common Disorders, 2e AB - Adverse drug reactions are typically classified into type A (augmented) and B (bizarre or idiosyncratic) reactions.1 Type A reactions are often predictable and cause dose-related toxicity, such as an increased risk of bleeding developing with a supratherapeutic INR (international normalized ratio) on warfarin. Type B reactions, on the other hand, are immune-mediated, allergic or intolerance reactions that often occur irrespective of the medication dose.2 Immune-mediated reactions can be further subdivided into immediate (often, but not always IgE mediated) reactions or delayed type, such as T-cell mediated reactions which can present with a variety of cutaneous and systemic manifestations.3 Immediate reactions occur within minutes to hours after medication exposure (usually after first exposure) and delayed type reactions appear hours or days after exposure to the drug. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - dermatology.mhmedical.com/content.aspx?aid=1190937824 ER -