TY - CHAP M1 - Book, Section TI - Extrinsic Aging A1 - Baumann, Leslie S. A1 - Weisberg, Edmund M. A2 - Baumann, Leslie S. A2 - Rieder, Evan A. A2 - Sun, Mary D. PY - 2022 T2 - Baumann’s Cosmetic Dermatology, 3e AB - SUMMARY POINTSWhat’s Important?The AhR signaling pathway is turned on by ozone and other pollutants and results in increased production of MMPs.The common deletion in mitochondria occurs in photoaged skin and is associated with decreased mitochondrial function.There is much overlap with intrinsic aging; therefore, reading Chapter 5 will provide useful supplemental information.What’s New?The ECM components are broken down with sun exposure and other extrinsic insults resulting in changes in fibroblast activity.Pollution from traffic is a major cause of skin aging.Infrared and visible light can age skin.What’s Coming?Knowledge on genetic expression and epigenetic methylation changes in sun-exposed vs. non-sun-exposed skin will increase.Studies on mitochondria and how to improve autophagy and mitochondrial function in aged skin are ongoing.It is still not possible to upregulate elastin levels in the skin by any means. Studies are ongoing to try and find ways to increase the quantity of mature elastin fibers that are bound to a microfibrillar backbone in the skin. SN - PB - McGraw Hill LLC CY - New York, NY Y2 - 2024/03/29 UR - dermatology.mhmedical.com/content.aspx?aid=1190667325 ER -