RT Book, Section A1 Goldfarb, Noah A1 Lin, Steven W. A2 Soutor, Carol A2 Hordinsky, Maria K. SR Print(0) ID 1177006734 T1 Skin Diseases of the Feet T2 Clinical Dermatology YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071769150 LK dermatology.mhmedical.com/content.aspx?aid=1177006734 RD 2024/04/19 AB The plantar surface of the foot has the thickest keratin layer, a high concentration of eccrine sweat glands, as well as sensory nerves, including Pacinian corpuscles, and other mechanoreceptors. The combination of abundant keratin and sweat creates an ideal environment for fungal infections. Friction and contact with footwear also make the feet susceptible to contact dermatitis. In addition, the feet are disproportionally affected by vascular disorders, due to their gravity-dependent anatomical location, and by peripheral small fiber sensory neuropathies. Since the feet are a site of frequent injury, vascular disorders and sensory neuropathies predispose this area to recurrent and difficult-to-manage wounds.